Yes — Lomé is generally safe for tourists who apply standard urban common sense. It is consistently rated one of the more stable and welcoming capitals in West Africa, with a low rate of violent crime against foreigners and a visible, if not heavy, security presence in the tourist and diplomatic zones.
The main risks are opportunistic: phone and bag snatching can occur around the Grand Marché, the beach at night, and the Ghana border crossing area. Keep valuables out of sight, use a money belt for passports and large amounts of cash, and avoid walking alone on unlit beach stretches after midnight.
Moto-taxis (zemidjans) are the city's main transport and are generally safe, but insist on a helmet and fix the fare before you climb on. For longer journeys or night travel, use a registered taxi app or have your hotel call a driver.
Political demonstrations have occasionally turned tense in recent years; monitor local news and keep away from any large gatherings. The Togolese security forces tend to disperse protests quickly.
Health-wise: take malaria prophylaxis, ensure yellow fever vaccination is up to date (it is an entry requirement), and drink bottled or filtered water throughout. The private Clinique de l'Union in central Lomé and the Hôpital de la Lomé Commune are the best options for medical care if needed.