Yes — Douala is generally safe for tourists and business travellers who take standard big-city precautions. The Littoral Region where Douala sits has remained stable, and the city receives a steady flow of expatriates, UN workers, and international business visitors year-round.
The main risks are opportunistic petty crime: pickpocketing in crowded markets (Sandaga, Marché Central), bag-snatching from car windows in slow traffic, and scams targeting visibly lost tourists. Avoid displaying expensive jewellery, cameras, or cash in busy areas. Use registered taxis or ride-hail apps (Yango is widely available) rather than flagging unmarked vehicles, especially at night.
After dark, stick to the main lit streets of Akwa and Bonanjo and avoid wandering into unfamiliar residential neighbourhoods alone. The areas around Bonabéri (across the Wouri Bridge) and parts of New Bell have higher crime rates and are best visited with a trusted local guide.
Importantly, Cameroon has an ongoing Anglophone crisis in the North West and South West regions — this does not affect Douala, but travellers should avoid those regions and check government travel advisories before visiting. Northern Cameroon near the Lake Chad basin also carries separate security risks unrelated to Douala.
Health-wise, yellow fever vaccination is mandatory for entry. Malaria prophylaxis is strongly recommended. Drink bottled or filtered water throughout your stay.