Yes — Darwin is generally safe for tourists, and most visits are trouble-free. The city has a relaxed, friendly atmosphere, and standard Australian safety standards apply throughout. However, there are a few specific hazards that every visitor must take seriously.
Crocodiles: This is the single most important safety message. Saltwater (estuarine) crocodiles inhabit Darwin Harbour, the rivers, coastal wetlands, and many waterways across the Top End. Never swim in, walk close to, or wade into any body of water outside designated safe swimming areas unless you have confirmed it is croc-free. Always heed 'No Swimming — Crocodiles' signs.
Marine stingers: Box jellyfish and irukandji jellyfish can be present in the sea from October to May. Swim only in stinger-netted enclosures during the Wet Season.
Heat and sun: Temperatures regularly exceed 35°C, and the UV index is extreme. Carry water at all times, wear a hat and sunscreen, and avoid exertion during midday hours when exploring the outback.
Petty crime: As in any city, keep an eye on valuables, especially around Mitchell Street at night. The CBD is generally safe after dark.
Safety resources: Australia's emergency number is 000. The NT Parks and Wildlife Service posts current crocodile warnings at park entrances and on their website.