Yes — Florence is generally very safe for tourists, and violent crime against visitors is rare. It consistently ranks among Italy's safest cities and is a popular destination for solo travellers, couples, families, and elderly visitors alike.
The main concern is petty theft, particularly pickpocketing. The highest-risk spots are the areas around the Uffizi, the Accademia, Ponte Vecchio, the Santa Maria Novella train station, and crowded bus routes (especially bus 12/13 to Piazzale Michelangelo and the C2 route). Keep your bag in front of you, use a money belt for passports and large amounts of cash, and be wary of strangers who approach with petitions or 'friendship bracelets' — these are common distraction scams.
Transport and navigation: Florence's historic centre is entirely walkable and well-lit at night. The city's small size means taxis are rarely needed for central destinations. Be cautious on the narrow pavements — mopeds and cyclists share lanes in unexpected places.
Health: No vaccinations are required beyond standard travel health precautions. European Health Insurance or travel insurance with medical cover is strongly recommended. Pharmacies (farmacie) are plentiful and pharmacists are highly trained — they can advise on minor ailments without a prescription.
LGBTQ+ travellers: Florence is generally welcoming. It hosts a Pride event annually and has an open, liberal urban culture, particularly in the Oltrarno and Santa Croce neighbourhoods.
Emergency numbers: Police 113, Carabinieri 112, Ambulance 118, Fire 115.